Entry of Academic Procession
The Chancellor, Deputy Chancellors, Vice-Chancellor, Deputy Vice-Chancellors, members of the University Council and staff of the University will enter in academic procession.
Indigenous Opening
Australian National Anthem
Opening of Proceedings
Presentation of Graduates
Closing of Proceedings
Departure of Academic Procession
The Chancellor, Deputy Chancellors, Vice-Chancellor, Deputy Vice-Chancellors, members of the University Council and staff of the University will exit in academic procession.
Chancellor
Mr John Hood
Deputy Chancellors
Ms Elizabeth Perry AM
Mr Douglas Gautier AM
President and Vice-Chancellor
Professor Colin J Stirling
Senior Deputy Vice-Chancellor (Students)
Professor Romy Lawson
Deputy Vice-Chancellor (Research)
Professor Ray Chan
Vice-President and Pro Vice-Chancellor (International)
Mr Sebastian Raneskold
Vice-President (Corporate Services)
Mr Mark Gregory
General Counsel & University Secretary
Mr Marc Davies
Business, Government and Law
Professor Michael Gilding
Education, Psychology and Social Work
Professor Deborah West
Humanities, Arts and Social Sciences
Professor Peter Monteath
Medicine and Public Health
Professor Jonathan Craig
Nursing and Health Sciences
Professor Alison Kitson
Science and Engineering
Professor Alistair Rendell
Name | Course |
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Eleanor Elizabeth Anderson | BACHELOR OF MEDICAL SCIENCE |
Nashmil Dolat Javid | BACHELOR OF MEDICAL SCIENCE |
Minori Bagya Edirisinghege | BACHELOR OF MEDICAL SCIENCE |
Thinuka Rachithmal Jayawickrama Withanage | BACHELOR OF MEDICAL SCIENCE |
Jiawei Jian | BACHELOR OF MEDICAL SCIENCE |
Huynh Nhu Nguyen | BACHELOR OF MEDICAL SCIENCE |
Abeer Rahel | BACHELOR OF MEDICAL SCIENCE |
Cathy Phuong Thanh Vu | BACHELOR OF MEDICAL SCIENCE |
Arogya Adhikari | BACHELOR OF NURSING |
Kien Tran | BACHELOR OF PARAMEDICINE |
Lana Mackenzie Turbill | BACHELOR OF PUBLIC HEALTH |
Aaron Clark | HONOURS DEGREE OF BACHELOR OF MEDICAL SCIENCE |
Benjamin Robert Hoy | HONOURS DEGREE OF BACHELOR OF MEDICAL SCIENCE |
Megan Frankenfeld | GRADUATE CERTIFICATE IN CLINICAL EDUCATION |
Yasmin Khanbhai | GRADUATE CERTIFICATE IN CLINICAL EDUCATION |
Naomi Margaret Wall | GRADUATE CERTIFICATE IN CLINICAL EDUCATION |
Ranjita Baniya | GRADUATE CERTIFICATE IN PUBLIC HEALTH |
Sylvia Kulesza | GRADUATE CERTIFICATE IN PUBLIC HEALTH |
Haidee Noonan | GRADUATE CERTIFICATE IN REMOTE HEALTH PRACTICE |
Xiaoxi Liu | GRADUATE DIPLOMA IN COGNITIVE BEHAVIOUR THERAPY |
Arminda Sony Graves | GRADUATE DIPLOMA IN COUNSELLING (BEHAVIOURAL HEALTH) |
Amber Leanne Rusby | GRADUATE DIPLOMA IN COUNSELLING (BEHAVIOURAL HEALTH) |
Joseph Loielo | GRADUATE DIPLOMA IN INTENSIVE CARE PARAMEDICINE |
Quang-Huy Nguyen | GRADUATE DIPLOMA IN INTENSIVE CARE PARAMEDICINE |
Fiona Raschella | GRADUATE DIPLOMA IN PUBLIC HEALTH |
Saumya Arora | MASTER OF BIOTECHNOLOGY |
Prakruthi Ravi Bhargav | MASTER OF BIOTECHNOLOGY |
Yu Xuan Fong | MASTER OF BIOTECHNOLOGY |
Kanchan Ghimire Shrestha | MASTER OF BIOTECHNOLOGY |
Mengyu Hu | MASTER OF BIOTECHNOLOGY |
Mahejbin Anish Karia | MASTER OF BIOTECHNOLOGY |
Sushma Koirala | MASTER OF BIOTECHNOLOGY |
Janvi Kamleshbhai Mistry | MASTER OF BIOTECHNOLOGY |
Mariya Francis Moonjely | MASTER OF BIOTECHNOLOGY |
Madhura Nagaraju | MASTER OF BIOTECHNOLOGY |
Jeel Viraj Patel | MASTER OF BIOTECHNOLOGY |
Krima Jitendra Patel | MASTER OF BIOTECHNOLOGY |
Aastha Ashokbhai Savaliya | MASTER OF BIOTECHNOLOGY |
Dimpy Sanjilkumar Sheth | MASTER OF BIOTECHNOLOGY |
Gia Han Tran | MASTER OF BIOTECHNOLOGY |
Carly Anne Jones | MASTER OF CLINICAL EDUCATION (BY COURSEWORK) |
Ratnayake Mudiyanselage Yasoda Lahiruni Abeyratne | MASTER OF COGNITIVE BEHAVIOUR THERAPY |
Victoria Daube | MASTER OF COGNITIVE BEHAVIOUR THERAPY |
Diana Jacqueline Nicodin | MASTER OF COGNITIVE BEHAVIOUR THERAPY |
Rachelle Bonus Abante | MASTER OF PUBLIC HEALTH |
Saika Tuz Zoha Chowdhury | MASTER OF PUBLIC HEALTH |
Fiona Cossey | MASTER OF PUBLIC HEALTH |
Charlene D Souza | MASTER OF PUBLIC HEALTH |
Sarah Kathleen Emmett | MASTER OF PUBLIC HEALTH |
Nagpriya Shekar Hangal | MASTER OF PUBLIC HEALTH |
Meena Subhanjali Jeevanbabu | MASTER OF PUBLIC HEALTH |
Doyce Jom | MASTER OF PUBLIC HEALTH |
Anne Kamau | MASTER OF PUBLIC HEALTH |
Navneet Kaur | MASTER OF PUBLIC HEALTH |
Jinhong Lin | MASTER OF PUBLIC HEALTH |
Kathryn Jane Moar | MASTER OF PUBLIC HEALTH |
James Fergus Guildford North | MASTER OF PUBLIC HEALTH |
Abimbola Abigail Obisesan | MASTER OF PUBLIC HEALTH |
Omotola Ebun Ogunmekan | MASTER OF PUBLIC HEALTH |
Palak | MASTER OF PUBLIC HEALTH |
Sejal Aakash Patel | MASTER OF PUBLIC HEALTH |
Jessica Penglis | MASTER OF PUBLIC HEALTH |
Nishtha Sarpal | MASTER OF PUBLIC HEALTH |
Angela Nassaazi Semanda | MASTER OF PUBLIC HEALTH |
Mohmadarman Mohmadharun Sheikh | MASTER OF PUBLIC HEALTH |
Mia Smudic | MASTER OF PUBLIC HEALTH |
Raheemat Sunmonu | MASTER OF PUBLIC HEALTH |
Amala Elizabeth Sunny | MASTER OF PUBLIC HEALTH |
Lorreta Swincer | MASTER OF PUBLIC HEALTH |
Elizabeth Natalie Tiernan | MASTER OF PUBLIC HEALTH |
Arpita Tyagi | MASTER OF PUBLIC HEALTH |
Jing Wang | MASTER OF PUBLIC HEALTH |
Jinping Wei | MASTER OF PUBLIC HEALTH |
Haydar Yunis | MASTER OF PUBLIC HEALTH |
Alexandra Martins Coffey-Oates | MASTER OF REMOTE AND INDIGENOUS HEALTH |
Rippan Neelkanth Shukla | MASTER OF SURGERY |
Neil Singh Arora | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Jonathon Cavuoto | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Nishan Chahal | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Isobel Charlotte Ross Chambers | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Aatmaj Dasondi | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Tejaspreet Kaur Ghataura | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Emily Jayne Gloede | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Hamish James Lucas Greenslade | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Ananya Gupta | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Jeremy Yu Xuan Kiew | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Sharveena Krishnan | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Richard Le | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Gowri Manesh | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Hamish Mckenzie | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Nadiah Amalina Binte Mustafa | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Daniel Duy Nguyen | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Irvin Chris Ong | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Jennifer Pham | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Thuy Trang Teresa Pham | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Sriram Raj | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Chrishma Ravindranath | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Lydia Jasmine Smalls | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Jessica Rui Ping Thia | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Jin Nuo Joan Tsang | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Claire Jiayi Yun | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Emilie Zhou | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE |
Mohsin Haseeb Ahmad | DOCTOR OF MEDICINE |
Pegah Ahmadiyan Ardestani | DOCTOR OF MEDICINE |
Ginger Kate Akins | DOCTOR OF MEDICINE |
Darya Ali | DOCTOR OF MEDICINE |
Kosta Antolis | DOCTOR OF MEDICINE |
Philip John Arundel | DOCTOR OF MEDICINE |
Svetlana Astashova | DOCTOR OF MEDICINE |
Rumsha Baig | DOCTOR OF MEDICINE |
Andrew James Baldwin | DOCTOR OF MEDICINE |
Joshua Clinton Bates | DOCTOR OF MEDICINE |
Milica Beljic | DOCTOR OF MEDICINE |
Amy Marie Booth | DOCTOR OF MEDICINE |
Chelsea Emma Boylan | DOCTOR OF MEDICINE |
Jasmin Alice Branford | DOCTOR OF MEDICINE |
John Robert Brennan | DOCTOR OF MEDICINE |
Rohan Alan Conway Broadhead | DOCTOR OF MEDICINE |
Samantha Jade Brookman | DOCTOR OF MEDICINE |
Michael Catalanotto | DOCTOR OF MEDICINE |
Pooja Chugh | DOCTOR OF MEDICINE |
Shaun Crouch | DOCTOR OF MEDICINE |
Prabjot Dhaliwal | DOCTOR OF MEDICINE |
Prabhsimran Dhillon | DOCTOR OF MEDICINE |
Kaavvya Divakaran | DOCTOR OF MEDICINE |
Natalie Clare Edmonstone | DOCTOR OF MEDICINE |
Verena Fanous | DOCTOR OF MEDICINE |
Salma Sherif Mohamed Fathy | DOCTOR OF MEDICINE |
Anushka Ghorpade | DOCTOR OF MEDICINE |
Holly Michelle Groome | DOCTOR OF MEDICINE |
Marina Emad Habib | DOCTOR OF MEDICINE |
Andrew Peter Hearl | DOCTOR OF MEDICINE |
Lucy Rose Heil | DOCTOR OF MEDICINE |
Danny Hill | DOCTOR OF MEDICINE |
Gahyun Hong | DOCTOR OF MEDICINE |
Jamie Hua | DOCTOR OF MEDICINE |
Jack Henry Jeanes | DOCTOR OF MEDICINE |
Kavindya Ishini Kariyawasam | DOCTOR OF MEDICINE |
Jorjina Kasparian | DOCTOR OF MEDICINE |
Marjan Khorvash | DOCTOR OF MEDICINE |
Laalithya Konduru | DOCTOR OF MEDICINE |
Reynier Evan Remo Lara | DOCTOR OF MEDICINE |
Kelvin Le | DOCTOR OF MEDICINE |
Andrew Leat | DOCTOR OF MEDICINE |
Madeleine Rose Lemmey | DOCTOR OF MEDICINE |
Michael Domenico Luppino | DOCTOR OF MEDICINE |
Eilish Rose Macauley | DOCTOR OF MEDICINE |
Grace Mackenzie | DOCTOR OF MEDICINE |
Thomas Simeon Mansfield | DOCTOR OF MEDICINE |
Ann Judith McDonald | DOCTOR OF MEDICINE |
Emma Maree McKenzie | DOCTOR OF MEDICINE |
Mohsen Moghimi | DOCTOR OF MEDICINE |
Lauren Marie Mormile | DOCTOR OF MEDICINE |
Agnes Wing Wa Ng | DOCTOR OF MEDICINE |
Thanh Phuong Nghi Patrick Nguyen | DOCTOR OF MEDICINE |
Megan Taylor Francis O'Reilly | DOCTOR OF MEDICINE |
Giang Trung Pham | DOCTOR OF MEDICINE |
Elena Andreea Popa | DOCTOR OF MEDICINE |
Alice Therese Quigley | DOCTOR OF MEDICINE |
Mahadya Rahman | DOCTOR OF MEDICINE |
Jonathan Ries | DOCTOR OF MEDICINE |
Alison Laura Rowley | DOCTOR OF MEDICINE |
Michelle Santella | DOCTOR OF MEDICINE |
Afia Schaefer | DOCTOR OF MEDICINE |
Laura Grace Schultz | DOCTOR OF MEDICINE |
Bophavotey Seng | DOCTOR OF MEDICINE |
Emily Claire Shaw | DOCTOR OF MEDICINE |
Gabrielle Edwina Pak-Poy Shea | DOCTOR OF MEDICINE |
Isabella Jane Sheehan | DOCTOR OF MEDICINE |
Marshall Benjamin Smith | DOCTOR OF MEDICINE |
Emily Jane Olivia Squires | DOCTOR OF MEDICINE |
Marat Sverdlov | DOCTOR OF MEDICINE |
Hannah Sweaney | DOCTOR OF MEDICINE |
Su Mon Thin Zar | DOCTOR OF MEDICINE |
Jessica Amy Thomas | DOCTOR OF MEDICINE |
Gabriel Gerard Tramaglino | DOCTOR OF MEDICINE |
Angela Vivish Vazhalanickal | DOCTOR OF MEDICINE |
Madeleine Nicole Veitch | DOCTOR OF MEDICINE |
Abigail Claire Watson | DOCTOR OF MEDICINE |
Eleanor Elizabeth Watts | DOCTOR OF MEDICINE |
Muhammad Ashraf Bin Yahya | DOCTOR OF MEDICINE |
Alex William Zahnleiter | DOCTOR OF MEDICINE |
Mary Liang Zhao | DOCTOR OF MEDICINE |
Matthew John Giddings | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE WITH DISTINCTION |
Naomi Yomana Kanahala Gamage | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE WITH DISTINCTION |
Nicholas Pavic | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE WITH DISTINCTION |
Benjamin Michael Dean Voyvodic | BACHELOR OF CLINICAL SCIENCES AND DOCTOR OF MEDICINE WITH DISTINCTION |
Joshua Thomas Andrews | DOCTOR OF MEDICINE WITH DISTINCTION |
Shannon Rose Capewell-Jones | DOCTOR OF MEDICINE WITH DISTINCTION |
Hannah Mary Carter | DOCTOR OF MEDICINE WITH DISTINCTION |
Alex James Coleman | DOCTOR OF MEDICINE WITH DISTINCTION |
James Laurence Fowler | DOCTOR OF MEDICINE WITH DISTINCTION |
Tessa Gaynor | DOCTOR OF MEDICINE WITH DISTINCTION |
Monica Susan Hansen | DOCTOR OF MEDICINE WITH DISTINCTION |
Stephanie Anne Louey | DOCTOR OF MEDICINE WITH DISTINCTION |
Madison Elizabeth Paula Lowe | DOCTOR OF MEDICINE WITH DISTINCTION |
Revania Kalini Pillay | DOCTOR OF MEDICINE WITH DISTINCTION |
Stephanie Joan Thomson | DOCTOR OF MEDICINE WITH DISTINCTION |
Benjamin Martin Weimann | DOCTOR OF MEDICINE WITH DISTINCTION |
Daniel Schultz Zaina | DOCTOR OF MEDICINE WITH DISTINCTION |
Name | Principal & Associate Supervisor | Thesis | Citation |
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Robert Adams | Professor Cedric Bardy & Stuart Bierley & Tomothy Sargeant | Relationships Between Bioenergetics, Physiological Activity, and Lysosome Function in Human Neurons | As the average human lifespan grows longer thanks to advances in medical care, the number of people suffering from late age neurological disorders increases. To relieve this increasing burden of suffering, new medical treatments are required. Parkinson’s Disease is one such disorder that has received decades of dedicated research, yet it has no cure. In recent years, a lack of brain energy has been suggested to play an important role in the disease. This research explored how brain cell functions suffer when deprived of energy. Specifically, it investigated how waste clearance mechanisms may become less efficient, and how brain cell to brain cell communication can be disrupted. It also explored restoring brain energy by lowering brain cell activity. Findings present a novel method for restoring brain energy that may hold therapeutic potential, and they improve upon our understanding of how a lack of energy can impact brain function. |
Thomas James Altree | Professor Danny Eckert & Associate Professor Sutapa Mukherjee & Professor Peter Catcheside | The effects of reboxetine and morphine on sleep and breathing in obstructive sleep apnea and chronic obstructive pulmonary disease. | This thesis assessed the effects of repurposed drugs during sleep in two common respiratory diseases, obstructive sleep apnea (OSA), and chronic obstructive pulmonary disease (COPD). Combined noradrenergic reuptake inhibitor and antimuscarinic drugs have shown promise as new treatments for OSA. It is unclear if reboxetine, a noradrenergic reuptake inhibitor, is effective without an antimuscarinic. In a randomized controlled trial, I showed that reboxetine improved OSA severity, and combining reboxetine with an antimuscarinic did not yield additive benefits. People with COPD frequently experience breathlessness. Low dose morphine is used for breathlessness, but there are safety concerns related to breathing and alertness. In a secondary analysis of a large randomized controlled trial, I showed that low dose morphine does not impair sleepiness or alertness over four weeks. In another randomized controlled trial, I showed that low dose morphine did not improve sleep quality in COPD, but lowered the breathing rate and oxygen levels during sleep. |
Jayalathge Dona Melanie Samanthi Amarasooriya | Professor Greg Bain & Dr Kimberley Ruxton & Dr Rami Al-Dirini | Assessment of in vivo kinematics of the normal and scapholunate instability wrist using dynamic CT scan | Scapholunate instability (SLI) is the most common carpal instability, accounting for 5% of wrist sprains. The diagnosis of SLI is often missed. Even when diagnosed and treated, the clinical outcomes are far from ideal. Possible reasons for this include the poor understanding of the biomechanics of SLI and objective dynamic assessment not being a major part of its management. In large joints, such as the knee or shoulder, surgical decisions are largely supported by dynamic assessment. The wrist, due to its complex anatomy, precludes such dynamic clinical assessment. In this context, dynamic (4D) CT provides a unique advantage due to its ability to scan the patients' wrist during movement. This doctoral thesis presents concepts and techniques to objectively measure kinematic changes in SLI compared to a normal wrist. These objectively measurable parameters enable better diagnosis, aid in surgical decision making, and provide insights into designing reconstruction techniques for SLI. |
Radwan Laurence Ansaar | Professor Robyn Meech & Dr Dong Gui Hu & Dr Julie-Ann Hulin | UDP‑Glycosyltransferases (UGTs) in Anti‑Cancer Drug Resistance | Resistance to anti cancer drugs represents a major hurdle in treating breast cancer. This project sought to understand the role of a drug metabolising enzyme called UGT2B7 in mediating resistance to chemotherapy. Expression of UGT2B7 in breast cancer cells was induced by chemotherapy; and in turn, high levels of UGT2B7 induced resistance to chemotherapy. Thus, UGT2B7 may be a biomarker of drug resistance and also a target for overcoming it. We further identified a mechanism by which co administering complementary anti cancer drugs could overcome the adverse effects of high UGT2B7 expression. This mechanism, referred to as pharmaco enhancement, might lead to the development of more effective chemotherapy regimens. Lastly, using the physiological characteristics of patients, we developed a whole body pharmacokinetic model that can be applied to predict plasma chemotherapy levels. This is a useful tool for determining optimised dosing, potentially paving the way for personalised therapies |
Xun‑Nan Chen | Dr Morton Burt & Campbell Henry Thompson & Dr Anjana Radhakutty | Cardiometabolic Effects of Glucocorticoid Excess: Inpatient Hyperglycaemia and in Adrenal Incidentaloma | Glucocorticoids are steroid hormones that produced by the adrenal glands and also used to treat many diseases. Glucocorticoid excess is associated with several adverse cardiometabolic effects. These include high blood glucose, high blood pressure and obesity. This thesis characterised underlying factors that may contribute to cardiometabolic risk in two clinical models of glucocorticoid excess. Firstly, it showed that five clinical factors including weight, sex, HbA1c, diabetes status and diabetes treatment contributed to approximately 65% of the variability in total insulin dose needed to treat high blood glucose in hospitalised patients receiving therapeutic glucocorticoids. Incorporation of these factors could optimise therapy and reduce cardiometabolic risk in this patient group. Secondly, it showed that impaired insulin secretion is a key mechanism that contributes to cardiometabolic risk in patients with benign adrenal gland tumours that secrete low levels of glucocorticoid in excess. Future considerations for diabetes management in this patient group is crucial. |
Philip Man Chiu Choi | Professor Maria Crotty & Professor Joseph Selvanayagam & Timothy Kleinig | Acute Ischemic Stroke Assessment: Overcoming Barriers to Effective Therapies | Stroke is a leading worldwide cause of death and disability. The effectiveness of acute stroke treatments is time sensitive, yet despite widespread awareness of this, and despite some quality improvement efforts, key Australian stroke treatment time metrics continue to compare poorly to other advanced health systems. Further, the gap is widening, as stroke reperfusion timeliness has not improved in Australia over the last six years. Optimising and expediting access to evidence based stroke treatments in Australia, would have a substantial population impact on post stroke outcomes. This thesis includes 9 publications from 2016 to 2023, describing the results and learnings of the Box Hill Hospital stroke team quality improvement program (the most time effective acute stroke team in Australia since 2020). Through these processes local stroke service delivery has substantially improved. If widely replicated, these strategies and approaches have the potential to enhance quality acute stroke care across Australian (and other International) stroke centres. |
Megan Kate Fowler | Associate Professor Mary‑Louise Rogers & Professor Jill Carr & Frances Theunisen | Endogenous retroviruses and the association with TDP 43 and inflammation in the cause and progression of Motor Neuron Disease | Motor Neuron Disease (MND) is a relentless neurological disorder with limited treatment options. The cause of MND remains unknown but endogenous retroviruses (ERVs) have been implicated in the cause and progression of neurodegeneration that is a hallmark of MND. Based on the involvement of ERVs in MND, the overall aim of my thesis was to investigate the influence of antiretroviral therapy on MND using a mouse model of MND. Also, my thesis aimed to understand the role of ERVs in cell models that recapitulate MND. To achieve these aims, the therapeutic benefit of antiretroviral therapy was assessed through established measures of disease progression and known hallmarks of MND disease pathology such as motor neuron degeneration. Investigating neurodegenerative mechanisms and determining the effectiveness of novel therapies is vital for progression towards MND being a treatable and curable disease |
David Lyndon Garne | Professor Lambert Schuwirth & Emeritus Professor Paul Worley & Ian Wilson | Learning to Think Like a Doctor: The Development of Clinical Reasoning in Medical Students During Longitudinal Integrated Clerkships. | Longitudinal integrated clerkships are becoming increasingly accepted worldwide as an alternative pedagogical approach to undergraduate training in medical schools. Anecdotal evidence suggests that students engaged in longitudinal models develop good clinical reasoning, but there is an almost complete lack of robust evidence to support this observation. This research investigated how and why students in these longitudinal models develop a solid foundation in clinical reasoning. Findings from the research showed that there are strong ontological similarities between clinical reasoning and longitudinal integrated clerkships, and this provides a logical explanation for this development. The unique affordances found in longitudinal clerkships combine in complex adaptive ways, and immersing students in these settings has a direct impact on the development of good clinical reasoning, which is also a complex adaptive construct. The research makes an original contribution to this important topic and provides important implications for the future of medical education. |
Max Hardwick‑Morris | Professor Mark Taylor & Dr Rami Al-Dirini & Joshua Twiggs | Prediction of Iliopsoas Tendonitis after Hip Arthroplasty | Iliopsoas tendonitis occurs in up to 30% of patients after hip arthroplasty surgery, and is most frequently attributed to impingement between an exposed anterior edge of the acetabular component and the iliopsoas. Despite its relatively high incidence, very little research has been directed towards computational modelling of this phenomenon to prevent its occurrence. Therefore, this dissertation sought to develop and validate a computational simulation that can detect impingement between the iliopsoas and acetabular cup, and then use this simulation to identify preoperative risk factors that exacerbate the risk of iliopsoas tendonitis. The ultimate ambitions for this tool were two fold. First, to be used diagnostically by enabling postoperative assessment of patients who are experiencing groin pain, and facilitate enhanced treatment selection for these patients. Second, this tool has been developed with the intention for it to be integrated into a preoperative planning platform to further optimise preoperative templating for hip arthroplasty surgery. |
Georgina Louise Hollitt | Professor Jamie Craig & Dr Emmanuelle Souzeau & Dr Owen Siggs | Understanding Polygenic Risk Testing and Risk Communication for Glaucoma | Glaucoma is the most common cause of irreversible vision loss in the world and is known to be highly heritable, with recognised monogenic and complex inheritance patterns. Recently, polygenic risk scores (PRS) have shown promise in stratifying individual glaucoma risk. However, despite significant advances in the understanding of the genetic underpinnings of glaucoma, important details about clinical implementation are not yet known. This thesis addresses this gap in knowledge, providing early insights into the future implementation of glaucoma PRS testing. My original contribution to knowledge included assessing attitudes of key stakeholders towards glaucoma PRS testing, developing novel PRS reports, and applying PRS testing in several clinical contexts. The outcomes of this thesis will bring glaucoma PRS significantly closer to clinical implementation, and therefore, in reducing global vision loss caused by the condition. |
Natansh Deepak Modi | Associate Professor Ash Hopkins & Professor Michael Sorich & Professor Andrew Rowland & Professor Ross McKinnon | Exploring the Value of Shared Clinical Trial Data: Policy, Application, and Impact | Transparent sharing of clinical trial data is important for scientific integrity, patient safety, and medical research advancement. Despite industry commitments, significant data accessibility gaps persist. This thesis demonstrates that while there has been progress, a substantial amount of valuable data from pivotal clinical trials remains inaccessible. Audits of individual participant data availability for high revenue and anticancer medicines emphasize the need for standardized, enforceable policies to ensure immediate data availability upon a medicine’s approval. The practical applications of enhanced data transparency are highlighted through the development of clinical prediction models and the integration of patient reported outcomes into clinical practice. These advancements enable personalized patient care, optimizing treatment safety and efficacy. Ultimately, this thesis advocates for a more transparent and collaborative research environment, honouring the contributions of clinical trial participants and advancing precision medicine. |
Richard Fraser Newland | Professor Rob Baker | The Development of Intraoperative Electronic Perfusion Data Processing to Improve the Practice of Cardiopulmonary Bypass. | The acquisition of intraoperative electronic perfusion data (EPD) holds immense potential for enhancing cardiopulmonary bypass (CPB) practices. Potentially the most important influence that EPD may have on clinical practice is the identification of modifiable predictors of patient outcome, and facilitation of quality improvement with integration into registries. The Australian and New Zealand Collaborative Perfusion Registry (ANZCPR) stands as a pioneer in the integration of EPD. This thesis includes 10 papers published between 2006 and 2022, reporting significant strides in CPB enhancement, including automated CPB quality indicator generation, establishment of the ANZCPR, and investigations into CPB's impact on patient outcomes including acute kidney injury and 30 day mortality. These efforts have influenced international CPB practice guidelines, advocating for EPD integration into registries for continuous quality monitoring and benchmarking. This groundwork paves the way for an international CPB registry, facilitating large scale studies and registry based trials to further refine CPB practices and patient outcomes. |
Lauren Alexandra Newman | Professor Andrew Rowland & Dr Zivile Useckaite & Michael Sorich | EVolving the Liquid Biopsy: Extracellular Vesicles for Assessing Liver Function and Disease | Liver cells release small membrane bound particles called extracellular vesicles (EVs) that have roles in communication between cells and disease progression. EVs can be found in bodily fluids, including blood, and carry molecular information reflecting organ function. In contrast to a solid tissue biopsy, EVs enable non invasive assessment and disease diagnosis in a “liquid biopsy”. Despite its promise, EV based liquid biopsy faces several challenges related to isolation from blood and analysis of molecular cargo. This thesis addresses barriers to clinical translation and advances the analytical framework for EV liquid biopsies. By specifically analysing liver derived markers from human blood samples, key metabolic functions of the liver can be assessed for disease staging and prediction of drug exposure and response to treatments. These contributions lay the foundation for personalised treatment strategies in liver disease and beyond. |
Yiming Wang | Professor Geraint Rogers & Professor Steve Wesselingh & Dr Steven Taylor | How does our mucus shape bacterial colonization?: Exploring mucosal glycosylation and gut microbiome dynamics | The findings described within this thesis establish an important association between a common human genetic polymorphism, the gut microbiome, and the potential to derive benefit from attempts to modulate host microbiome interactions using probiotics. The insight gained into the influence of genetic polymorphisms and bacterial dynamics have profound and far reaching consequences for the development and interpretation of probiotic interventions. |
Michael Alexander Zabolocki | Professor Cedric Bardy Stuart Brierley | Recapitulating human brain electrophysiology with induced pluripotent stem cell patient derived neurons | The human brain is one of the most complex organs in the body, responsible for many aspects of cognitive function and affected in numerous neurological diseases. Despite studies in existing animal models, neurological diseases are still a leading cause of disability and second leading cause of death world wide. This is largely attributed to differences between the brain of human and nonhuman species, especially in network development and electrical activity. Michael Zabolocki's thesis showed that human induced pluripotent stem cell derived neuronal models (minibrains) can recapitulate human specific electrical activity at the single cell level. Further, this work revealed that caudal interneurons are the cell type of origin for paediatric epilepsy. Together, this body of work demonstrated that human electrical activity can be modelled within the lab in a health and disease context. As a result, this is a significant step forward in developing innovative drug targets to treat human neurological diseases, such as paediatric epilepsy. |
Jett Zivkovic | Associate Professor Yoichiro Otsuka & Professor Jill Carr | The Thermoregulatory Response to Lithium & its Inhibition of Stress Induced Physiological & Behavioural Changes: A Novel Mechanism of Action & Brain Pathway | Lithium, the gold standard treatment for bipolar disorder, has an unknown mechanism of action. This thesis investigated physiological and behavioural responses to lithium in guinea pigs and rats, inspired by John Cade's discovery of lithium's therapeutic potential in 1949. We revealed a coordinated thermoregulatory response, challenging conventional views of lithium toxicity. Lithium reduced body temperature, brown adipose tissue (BAT) thermogenesis, and locomotor activity, while inhibiting stress induced BAT thermogenesis, emotional hyperthermia, and hyperlocomotion. These findings suggest lithium directly counteracts mechanisms triggered by psychological stress. We identified two brain pathways for lithium's effects, involving the area postrema and the hypothalamomedullary thermoregulatory network. Our research provides a fresh perspective on lithium's therapeutic mechanisms, implicating specific brain regions involved in psychological stress and stress related psychiatric conditions, which lithium is used to treat, and suggests clinical applications such as using lithium to prevent drug induced hyperthermia and potential strategies for mitigating lithium associated weight gain. |
Name | Award | Citation |
---|---|---|
Mrs Patricia Vilimas | Doctor of Science honoris causa | 2024 marks the 50th year of continuous employment of Patricia Vilimas (Pat) at Flinders University. While this is an outstanding achievement within any organisation, Pat’s achievements are not based solely on longevity. Rather, they are best reflected by her outstanding contributions to both Flinders and to medical research. Pat began work as a technical assistant at Flinders in 1975 within research groups focused on decoding the chemical components of the nervous system and the fundamental pathways they control. She first joined the research teams led by Professor John Furness and the late Professor Marcello Costa, who both became Fellows of the Australian Academy of Science. This team created new ways of studying the gut nervous system. Continuous innovation was required to make this work and much of this work was undertaken by Pat. Pat developed a reputation for her thoroughness and problem-solving capacity to produce data that ultimately informed researchers from across the globe on the form and function of the enteric (gut) nervous system. Pat subsequently became a research assistant in the laboratories headed by Professor Ian Gibbins and Professor Judy Morris. In this 30-year period, Pat was central in undertaking research that was pivotal to the creation of new knowledge in the field of autonomic neuroscience. The excellence of this research is exemplified by the fact that this team was constantly funded throughout this period by peak funding bodies, such as the National Health and Medical Research Council. The quality of Pat’s research was fundamental to this ongoing success in a time when funding rates were, and remain, challenging. What makes her contributions even more remarkable is that for much of her career she worked part-time, to manage family life. Pat currently undertakes a research support role within the College of Medicine and Public Health’s Microscopy facility, where she continues to teach and support students and young scientists in their own research. Based on her humility to remain in the background, Pat chose not to be a co-author on most of her research. However, she is officially ‘acknowledged’ in over 100 peer-reviewed publications, demonstrating her contributions to these works. The impact of this research is illustrated by these publications being cited over 8,000 times by others in the field, a record many Professors will not achieve in their career. Pat’s research career is best highlighted by the words of Pat’s long-time colleague and friend, Professor Ian Gibbins; “In Greek mythology, Hero was a priestess who was famous for her acts of self-sacrifice. If a priestess can be a source of otherwise hidden knowledge, and if living a life of science funded by the vagaries of the granting system counts as some kind of sacrifice, then Pat Vilimas is a true Hero in every sense of the word.” Apart from a Deans Award from the College of Medicine in 2004, Pat’s contribution to Flinders University and scientific research has largely gone unrecognised. We now wish to appropriately recognise this outstanding professional staff member and woman. In recognition of the excellence and rigour of her scientific work within the College of Medicine and Public Health at Flinders University, Patricia Vilimas is awarded a Doctor of Science honoris causa. |
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